COVID-19 Third Dose Vaccine Safety In opposition to Hospitalization Wanes After 3 Months

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Three COVID-19 Vaccine Doses

A brand new analysis research printed in The Lancet Respiratory Drugs exhibits that safety towards the omicron variant deteriorates over time – even after a 3rd vaccine dose.

Kaiser Permanente finds the Pfizer COVID-19 third dose vaccine safety towards hospitalization from omicron wanes after 3 months.

A analysis research launched on April 22, 2022, in The Lancet Respiratory Drugs exhibits {that a} booster dose of the Pfizer COVID-19 vaccine offers sturdy safety, roughly 80% to 90%, within the first few months towards hospital admissions and emergency division visits brought on by the delta and omicron variants of COVID-19. Nonetheless, this safety towards omicron deteriorates over time – even after a 3rd vaccine dose.

“Pfizer BioNTech COVID-19 booster doses considerably enhance safety towards omicron, though that safety appears to wane after 3 months towards emergency room visits, and even for hospitalization,” mentioned the research’s lead creator, Sara Y. Tartof, PhD, an epidemiologist with the Kaiser Permanente Southern California Division of Analysis & Analysis and a school member of the Kaiser Permanente Bernard J. Tyson Faculty of Drugs, each in Pasadena. “Tendencies in waning towards delta-related outcomes have been usually just like omicron, however with larger effectiveness at every time level than these seen for omicron.”

The researchers examined 11,123 hospital admissions and emergency division visits that didn’t end in hospitalization for acute respiratory an infection for this research. The researchers checked out Kaiser Permanente affected person data in Southern California from December 1, 2021, to February 6, 2022, when each the delta and omicron variants have been circulating within the inhabitants.

  • After 2 doses of the Pfizer COVID-19 vaccine effectiveness towards omicron was 41% towards hospital admission and 31% towards emergency division visits at 9 months.
  • After 3 doses, effectiveness towards omicron-related hospitalization was 85% at lower than 3 months however fell to 55% at 3 months or longer.
  • In opposition to emergency division visits that didn’t end in hospitalization, vaccine effectiveness of three doses towards omicron was 77% at lower than 3 months however fell to 53% at 3 months or longer.

“Though the Pfizer COVID-19 safety ranges towards omicron after 3 doses are considerably larger than these seen after 2 doses, they’re lower than these noticed for delta or different COVID-19 strains,” Tartof mentioned. “Extra doses of present, tailored, or novel COVID-19 vaccines could also be wanted to keep up excessive ranges of safety towards subsequent waves of COVID-19 brought on by omicron or future variants with comparable potential to flee safety.”

Reference: “Sturdiness of BNT162b2 vaccine towards hospital and emergency division admissions because of the omicron and delta variants in a big well being system within the USA: a test-negative case–management research” by Sara Y Tartof, PhD; Jeff M Slezak, MS; Laura Puzniak, PhD; Vennis Hong, MPH; Fagen Xie, PhD; Bradley Ok Ackerson, MD; Srinivas R Valluri, PhD; Luis Jodar, PhD and John M McLaughlin, PhD, 22 April 2022, The Lancet Respiratory Drugs.
DOI: 10.1016/S2213-2600(22)00101-1


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